Measuring the Trend of Use of Targeted Therapy and Economic Evaluation of Gefitinib for Advanced Non-Small Cell Lung Cancer (Nsclc) in Singapore.

Sensitivity analysis » The results of one way sensitivity analysis are shown in Fig 3. ICUR was most sensitive to the cost of Gefitinib. Other important parameters identified include PD to Die rate, SD to PD rate and utilites values for all the responses. Varying the PFS HR for CP also affected the ICUR. Characteristic Gefitinib (N=124) Age – Mean (± SD) 67.2 ± 10.4 Male 20.2 % Female 79.8 % Median duration of treatment (days) 278 (28-1627) Chinese 92.7 % Malay 4.8 % Indian 1.6 % Never smoker 85.5 % Smoker 2.4 % Former smoker 12.1 % Non-adenocarcinoma 6.5 % Adenocarcinoma 91.1 % Unknown histology 2.4 % Stage IIIb at entry 12.1 % Stage IV at entry 87.9 % EGFR positive 34.7 % Unknown EGFR status 65.3 % Introduction